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Princess Alexandrine of Prussia (23 February 1803–21 April 1892), Grand Duchess of Mecklenburg-Schwerin, was the daughter of Frederick William III of Prussia and Louise of Mecklenburg-Strelitz.
In 1822, she married Paul Friedrich, Grand Duke of Mecklenburg-Schwerin and had two sons and a daughter, including Friedrich Franz II of Mecklenburg-Schwerin.